Hippocampal volume and treatment outcome in postpartum depression: Naturalistic data from a psychiatric parent-baby unit

Our findings offer novel insights, highlighting an association between reduced hippocampal volume and improved treatment outcome in PPD. Widespread cortical grey matter reductions across the peripartum period have been linked to enhanced mother-infant bonding and may hence play a beneficial role in the therapeutic trajectory of PPD. Contrasting patterns typically observed in MDD, this inverse relationship further underlines distinct neurobiological features of PPD.