Specialists’ perceptions of clinical instruments, practices, and staging of DS‐AD: Results from an international survey
Personality, social behavior, language, mood/affect, memory, executive functioning, and attention are recognized as key domains of impairment in both mild cognitive impairment in Down syndrome (MCI-DS) and Down syndrome-associated Alzheimer's disease (DS-AD). Ten prominent informant and direct assessment tools were noted as appropriate for individuals with DS and mild to moderate intellectual disability (ID) for identifying both MCI-DS and DS-AD; however, for individuals with severe/profound ID, there was less assurance of applicability. Harmonizing recommended tools in a standardized list was identified as a strategy to promote consistency across clinical and research contexts.
Authors
- Hampus Hillerstrom
- Natalia S. Rozas (ORCID: https://orcid.org/0000-0003-0848-0478)
- Stephanie L. Santoro (ORCID: https://orcid.org/0000-0002-4172-0288)
- Matthew P. Janicki (ORCID: https://orcid.org/0000-0003-1053-1748)
- Amit Das (ORCID: https://orcid.org/0000-0002-2834-3158)
Institutions
- Boston Biomedical Research Institute (US)
- Foundation Fighting Blindness (US)
- University of Illinois Chicago (US)
- Massachusetts General Hospital (US)
- Massachusetts General Court (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/alz.70356
- Primary Topic
- Healthcare Systems and Technology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Eli Lilly and Company
- Centers for Disease Control and Prevention
- University of Illinois at Urbana-Champaign
- University of Illinois at Chicago
- National Center for Chronic Disease Prevention and Health Promotion