Molecular epidemiology and pretreatment drug resistance of HIV-1 among newly diagnosed individuals in Nanning City, Guangxi, China

This study highlights the growing challenge of pretreatment drug resistance (PDR) among newly diagnosed individuals with HIV in Nanning City. As antiretroviral therapy (ART) coverage expands, the persistence and transmission of drug-resistant strains pose a significant barrier to long-term treatment success. By documenting trends in PDR and identifying associated factors within a large representative sample, this study offers timely and actionable insights for clinicians and public health policymakers. The identification of key resistance mutations and clustering patterns, particularly in the CRF08_BC subtype, provides a critical foundation for tailored intervention strategies. Overall, these findings address a significant regional data gap and contribute to the optimization of HIV treatment and prevention efforts in China.