IL1β signaling mediates the interaction between hepatitis B and C viruses
Our findings reveal a macrophage-derived, IFN-independent mechanism by which HCV suppresses HBV infection, mediated through IL1β. These insights highlight the complex crosstalk between hepatotropic viruses during coinfection and suggest that targeting IL1β-regulated pathways may offer therapeutic potential to prevent HBV reactivation in DAA-treated patients.
Authors
- Lu Bian
- Zhiquan Feng (ORCID: https://orcid.org/0000-0002-7704-4197)
- Suan‐Sin Foo (ORCID: https://orcid.org/0009-0007-8174-0893)
- Yingpu Yu (ORCID: https://orcid.org/0000-0003-4837-5744)
- Liqun Ning (ORCID: https://orcid.org/0000-0002-3651-7410)
- Andrew C. Kwong (ORCID: https://orcid.org/0000-0002-0052-5881)
- Eun‐Hee Ha (ORCID: https://orcid.org/0000-0002-4224-3858)
- Egan Sanchez (ORCID: https://orcid.org/0000-0003-2340-406X)
- Shuyang Chen (ORCID: https://orcid.org/0000-0002-4760-4106)
- Fan Zhang (ORCID: https://orcid.org/0000-0001-8384-8637)
- Yujie Zhang (ORCID: https://orcid.org/0000-0001-9429-5193)
- Xianfang Wu (ORCID: https://orcid.org/0000-0002-2995-935X)
- Viet Loan Dao Thi (ORCID: https://orcid.org/0000-0003-2293-3592)
- Xinjia Wang (ORCID: https://orcid.org/0000-0003-1016-4669)
- Yuanyuan Zhao (ORCID: https://orcid.org/0000-0002-9992-2536)
- Weiqiang Chen (ORCID: https://orcid.org/0009-0005-4641-0923)
- Jianjun Wu (ORCID: https://orcid.org/0000-0001-5338-7032)
- Lei Wang (ORCID: https://orcid.org/0000-0002-8240-9795)
- Weibo Chen (ORCID: https://orcid.org/0000-0002-4727-3642)
- Kyle O’Shaughnessy (ORCID: https://orcid.org/0009-0005-3517-7345)
Institutions
- Cleveland State University (US)
- Cleveland Clinic (US)
- Harvard University (US)
- Heidelberg University (DE)
- University Hospitals of Cleveland (US)
- University Hospital Heidelberg (DE)
- Cleveland Clinic Lerner College of Medicine (US)
- Case Western Reserve University (US)
- Rockefeller University (US)
- Heidelberg University (US)
Publication Details
- Journal
- Hepatology
- Published
- 2025-09-12
- DOI
- https://doi.org/10.1097/hep.0000000000001525
- Citations
- 2
- Primary Topic
- Hepatitis C virus research
- Type
- article
- Field-Weighted Citation Impact
- 2.64