The dual role of interleukin-22: balancing protection and risk in pregnancy during inflammatory challenges
Interleukin-22 emerges as a promising therapeutic target in reproductive medicine, offering potential avenues for preserving pregnancy in the face of inflammatory challenges. However, increased levels of IL-22 could be associated with reproductive failures, emphasizing the delicate balance required for immune regulation. Our study underscores the importance of immune regulation in reproductive health and highlights IL-22 as a novel candidate for improving pregnancy outcomes in inflammatory conditions.
Authors
- Joanne Kwak‐Kim (ORCID: https://orcid.org/0000-0002-8409-1645)
- Héctor Rasgado-Flores (ORCID: https://orcid.org/0000-0001-9360-4783)
- Umida Ganieva (ORCID: https://orcid.org/0000-0001-9890-8946)
- Ana-Maria Adam (ORCID: https://orcid.org/0009-0004-8695-5381)
- Mahmood Bilal (ORCID: https://orcid.org/0000-0002-7370-0329)
- Wren E. Michaels (ORCID: https://orcid.org/0000-0003-1928-7956)
- Thanh Luu (ORCID: https://orcid.org/0000-0003-4200-5603)
- Amy Thees (ORCID: https://orcid.org/0000-0003-3015-7239)
- Svetlana Dambaeva (ORCID: https://orcid.org/0000-0002-1145-1814)
- Cecilia Peña‐Rasgado (ORCID: https://orcid.org/0000-0003-3565-3477)
Institutions
- Rosalind Franklin University of Medicine and Science (US)
Publication Details
- Journal
- F&S Science
- Published
- 2025-09-09
- DOI
- https://doi.org/10.1016/j.xfss.2025.09.001
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.00