Immunologic investigation of an allergic transfusion reaction suspected due to alpha‐gal syndrome
We report a case of anaphylactic shock in an O patient transfused with a B platelet unit. The in vitro data suggest, but do not prove, that the reaction was mediated by recipient alpha-gal IgE. Further studies are needed to establish whether transfusion-related alpha-gal syndrome ("TRAGS") is a true clinical entity.
Authors
- Nancy M. Dunbar (ORCID: https://orcid.org/0000-0001-8601-5438)
- Sean R. Stowell (ORCID: https://orcid.org/0000-0002-1130-9551)
- Zbigniew M. Szczepiorkowski (ORCID: https://orcid.org/0000-0003-2357-9564)
- Nora Ratcliffe
- Anne Huynh (ORCID: https://orcid.org/0000-0001-8462-6198)
- Shailesh K. Choudhary (ORCID: https://orcid.org/0000-0002-8160-6711)
- Richard M. Kaufman (ORCID: https://orcid.org/0000-0002-0041-804X)
- Brian C. Spence (ORCID: https://orcid.org/0000-0002-9613-0795)
- Scott P. Commins (ORCID: https://orcid.org/0000-0003-1198-2428)
- Hirotomo Nakahara (ORCID: https://orcid.org/0000-0001-7876-6557)
- Mark A Cervinski (ORCID: https://orcid.org/0000-0001-5116-3780)
- Mitchell C. Fuller
- Andrew Yanik
- Victoria Jones (ORCID: https://orcid.org/0009-0003-1202-9257)
Institutions
- University of North Carolina at Chapel Hill (US)
- Brigham and Women's Hospital (US)
- Dartmouth–Hitchcock Medical Center (US)
Publication Details
- Journal
- Transfusion
- Published
- 2025-09-12
- DOI
- https://doi.org/10.1111/trf.18405
- Citations
- 3
- Primary Topic
- Food Allergy and Anaphylaxis Research
- Type
- article
- Field-Weighted Citation Impact
- 4.87