<scp>SARS</scp> ‐ <scp>CoV</scp> ‐2 convalescent plasma for the controlled clinical trial “ <scp>COVIC</scp> ‐19”: Experience from collection of very high‐titer plasma from superimmunized individuals
We demonstrate the feasibility of the collection of very high-titer CCP products under a harmonized protocol for a randomized clinical trial, but it requires substantial donor selection, appropriate antibody assays, rapid succession of screening, and apheresis to take advantage of the short period of very high antibody concentrations.
Authors
- Thomas Burkhardt (ORCID: https://orcid.org/0000-0002-8410-088X)
- Patrick Wuchter (ORCID: https://orcid.org/0000-0001-9482-2870)
- Pierre Tiberghien (ORCID: https://orcid.org/0000-0002-9310-8322)
- Carolin Ludwig (ORCID: https://orcid.org/0000-0001-8820-8479)
- Bernd Jahrsdörfer (ORCID: https://orcid.org/0000-0002-8334-5244)
- Sixten Körper (ORCID: https://orcid.org/0000-0002-6590-0283)
- Eva Vanessa Schrezenmeier (ORCID: https://orcid.org/0000-0002-0016-7885)
- Christiane Vieweg
- Henrike Hofmann
- Alina Seidel (ORCID: https://orcid.org/0000-0001-7975-3790)
- Thomas Appl
- Rebecca Müller (ORCID: https://orcid.org/0000-0003-0790-9009)
- Hubert Schrezenmeier (ORCID: https://orcid.org/0000-0003-1222-6659)
- Harald Klüter (ORCID: https://orcid.org/0000-0002-5460-2897)
- Jan Münch (ORCID: https://orcid.org/0000-0001-7316-7141)
- Michael Schmidt (ORCID: https://orcid.org/0000-0001-9338-0900)
- Simone Hoffmann (ORCID: https://orcid.org/0000-0003-3690-2498)
- Matthias Johnsen
Institutions
- Inserm (FR)
- Universität Ulm (DE)
- Heidelberg University (DE)
- German Red Cross (DE)
- University Hospital Heidelberg (DE)
- Immungenetics (Germany) (DE)
- Établissement Français du Sang (FR)
- Université Marie et Louis Pasteur (FR)
- Charité - Universitätsmedizin Berlin (DE)
- Université de Franche-Comté (FR)
Publication Details
- Journal
- Transfusion
- Published
- 2025-09-12
- DOI
- https://doi.org/10.1111/trf.18394
- Citations
- 1
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- European Commission
- Bundesministerium für Bildung und Forschung