Sustained mood improvement with laughing gas exposure (SMILE): a randomised, placebo-controlled pilot trial of nitrous oxide for treatment-resistant depression
The findings support the feasibility and necessity of conducting a full-scale trial comparing nitrous oxide and midazolam in patients with TRD.
Authors
- Fatemeh Gholamali Nezhad
- Wendy Y. W. Lou (ORCID: https://orcid.org/0000-0001-5590-8719)
- Janneth Pazmino‐Canizares (ORCID: https://orcid.org/0000-0001-6842-8941)
- Gabriella F Mattina
- Duminda N. Wijeysundera (ORCID: https://orcid.org/0000-0002-5897-8605)
- Jiwon Lee (ORCID: https://orcid.org/0000-0002-7903-1883)
- Sidney H. Kennedy (ORCID: https://orcid.org/0000-0001-5339-7185)
- Karim Shiraz Ladha (ORCID: https://orcid.org/0000-0001-7303-2458)
- Vanessa K. Tassone (ORCID: https://orcid.org/0000-0002-9208-8809)
- Fathima Adamsahib
- Vineet Bhat (ORCID: https://orcid.org/0000-0001-6208-2804)
Institutions
- St. Michael's Hospital (CA)
- University of Toronto (CA)
- Toronto Western Hospital (CA)
- Women's College Hospital (CA)
- St Michael’s Hospital (IE)
- Public Health Ontario (CA)
- Unity Health Toronto
Publication Details
- Journal
- BJPsych Open
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1192/bjo.2025.10823
- Citations
- 1
- Primary Topic
- Neuroscience of respiration and sleep
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- Pfizer
- Sunovion
- Servier