Ancestral genomic functional differences in oligodendroglia: implications for Alzheimer's disease
First study comparing iPSC-derived oligodendroglia across three ancestries. APOE ε4 carriers show upregulated cholesterol synthesis in oligodendroglia. Reduced myelin gene expression observed in APOE ε4/ε4 oligodendroglia. Ancestry-specific differences found in AD GWAS genes and chromatin states. Novel insights into oligodendrocyte biology relevant to Alzheimer's disease.
Authors
- Mario Cornejo‐Olivas (ORCID: https://orcid.org/0000-0001-6313-5680)
- Juan I. Young
- Derek M. Dykxhoorn (ORCID: https://orcid.org/0000-0002-4998-9943)
- Maryenela Illanes‐Manrique (ORCID: https://orcid.org/0000-0002-3098-0981)
- Sofia Moura (ORCID: https://orcid.org/0000-0002-9000-2290)
- Farid Rajabli (ORCID: https://orcid.org/0000-0001-5229-7254)
- Patrice L. Whitehead
- Goldie S. Byrd (ORCID: https://orcid.org/0000-0003-1057-0261)
- Michael L. Cuccaro (ORCID: https://orcid.org/0000-0003-4769-0785)
- Jeffery M. Vance (ORCID: https://orcid.org/0000-0003-3815-8199)
- Aura M. Ramírez (ORCID: https://orcid.org/0009-0007-8892-5743)
- Brooke A. DeRosa (ORCID: https://orcid.org/0000-0002-7878-9799)
- Briseida E. Feliciano‐Astacio (ORCID: https://orcid.org/0000-0003-4747-8928)
- Takiyah D. Starks (ORCID: https://orcid.org/0000-0001-7267-3480)
- Margaret Ann Pericak‐Vance (ORCID: https://orcid.org/0000-0001-7283-8804)
- Luciana Bertholim Nasciben (ORCID: https://orcid.org/0009-0002-1518-1409)
- Pedro Mena (ORCID: https://orcid.org/0000-0003-2150-2977)
- Sergio Tejada
- Fulai Jin
- Anthony J. Griswold (ORCID: https://orcid.org/0000-0003-1925-7810)
- Lauren Coombs
- Maria C Robayo
- Liyong Wang (ORCID: https://orcid.org/0000-0001-8299-2602)
- Wanying Xu (ORCID: https://orcid.org/0000-0002-9633-232X)
- Allison Caban‐Holt (ORCID: https://orcid.org/0000-0001-5393-9116)
- Larry D. Adams
- Katalina McInerney
Institutions
- University of Miami (US)
- Central University of the Caribbean (PR)
- Universidad Científica del Sur (PE)
- Dr. John T. Macdonald Foundation (US)
- Instituto Nacional de Ciencias Neurológicas
- Wake Forest University (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/alz.70593
- Citations
- 2
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- Alzheimer's Association
- BrightFocus Foundation
- University of Miami
- Leonard M. Miller School of Medicine