Dual Growth Factor Release From Collagen Based Multilayer Films on Ti‐Surfaces Enhances Periimplant Bone Formation and Angiogenic Activity—An Experimental In‐Vivo Study
It is concluded that simultaneous release of rhBMP-2 and rhVEGF165 may be required to achieve significant improvement of periimplant bone formation and bone implant contact. Angiogenesis as reflected by CD31 expression is enhanced by both rhVEGF165 and rhBMP-2 to a similar extent without an additive effect of simultaneous release.
Authors
- Philipp Kauffmann (ORCID: https://orcid.org/0000-0002-1757-9165)
- Christian Dullin (ORCID: https://orcid.org/0000-0003-4297-8077)
- Susanne Wolfer (ORCID: https://orcid.org/0000-0002-4134-2301)
- Uwe Schirmer (ORCID: https://orcid.org/0000-0002-2402-4280)
- Henning Schliephake (ORCID: https://orcid.org/0000-0002-2008-7188)
- Klaus Liefeith (ORCID: https://orcid.org/0000-0002-8122-4481)
- Christina Behrens (ORCID: https://orcid.org/0000-0001-5734-3053)
- Pauline Schlosser
Institutions
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Max Planck Institute for the Study of Religious and Ethnic Diversity (DE)
- Institute for Bioprocessing and Analytical Measurement Techniques (DE)
- Max Planck Institute for Multidisciplinary Sciences (DE)
- University of Göttingen (DE)
Publication Details
- Journal
- Clinical Oral Implants Research
- Published
- 2025-09-12
- DOI
- https://doi.org/10.1111/clr.70045
- Primary Topic
- Bone Tissue Engineering Materials
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft