Radical Cascade Nitro-Cyclization Reaction of Oxygen-Linked 1,7-Dienes for the Synthesis of NO<sub>2</sub>-Substituted Benzoxepines
A series of nitro-benzoxepines were prepared from easily available oxygen-linked 1,7-dienes by using K<sub>2</sub>S<sub>2</sub>O<sub>8</sub> as the oxidant and NaNO<sub>2</sub> as the nitrogen source. This approach features mild conditions, readily accessible reagents, simple operation, and broad substrate applicability. Mechanistic studies suggest that the reaction proceeds through a radical pathway.
Authors
- Xiaowei Zhao (ORCID: https://orcid.org/0000-0002-1182-4502)
- A. V. Pan (ORCID: https://orcid.org/0000-0001-5313-4975)
- Nengneng Zhou (ORCID: https://orcid.org/0000-0003-1079-226X)
- Man Zhang (ORCID: https://orcid.org/0009-0007-4481-0514)
- Wanqing Zhao
- J. Y. C. CHU
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Ministry of Education (BD)
- Anhui Normal University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-09-12
- DOI
- https://doi.org/10.1021/acs.joc.5c01739
- Citations
- 1
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.94