Correlations between receptor occupancy change and mental state in patients using long-acting injectable antipsychotics: MIDILIA pilot study
Our novel observational study design has been demonstrated to be feasible and practicable. Faster reductions in D<sub>2</sub> occupancy may increase the risk of increased positive psychotic symptoms and irritability. Slower reductions may minimise this effect. Further recruitment is required before this can be confirmed.
Authors
- Lewis Couchman (ORCID: https://orcid.org/0000-0002-0464-7886)
- Samantha L. McLean (ORCID: https://orcid.org/0000-0001-9328-8928)
- George Crowther (ORCID: https://orcid.org/0000-0002-5102-4593)
- Mark Horowitz (ORCID: https://orcid.org/0000-0003-1318-2029)
- Muhammad Faisal (ORCID: https://orcid.org/0000-0003-4885-4251)
- James R. O’Neill (ORCID: https://orcid.org/0000-0001-8664-8825)
- Chris Wilson (ORCID: https://orcid.org/0000-0001-8494-0697)
- Kevin Lawlor
- Michael F. Dixon
Institutions
- University of Leeds (GB)
- University of Bradford (GB)
- King's College London (GB)
- North East London NHS Foundation Trust (GB)
- Analytical Services (US)
- Leeds and York Partnership NHS Foundation Trust (GB)
- South West Yorkshire Partnership NHS Foundation Trust (GB)
- NIHR Research Delivery Network (GB)
- National Patient Safety Foundation (US)
Publication Details
- Journal
- BJPsych Open
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1192/bjo.2025.10831
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Leeds