State‐dependent regulation of the K <sub>v</sub> 7.2 channel voltage sensor by QO‐58
Key contacts underlying sensitivity to VSD-targeted potentiators may vary significantly depending on the chemical and steric features of the drug. We anticipate that further investigation of VSD-targeted drugs will continue to clarify the complex pharmacophore of the VSD binding pocket in K<sub>V</sub>7 channels.
Authors
- Harley T. Kurata (ORCID: https://orcid.org/0000-0003-4357-4189)
- Shawn M. Lamothe (ORCID: https://orcid.org/0000-0001-8722-2631)
- Thomas M. Hammond (ORCID: https://orcid.org/0000-0002-0812-4759)
- Richard Kanyo (ORCID: https://orcid.org/0000-0002-8059-9628)
Institutions
- University of Alberta (CA)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-09-12
- DOI
- https://doi.org/10.1111/bph.70186
- Primary Topic
- Ion channel regulation and function
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alberta Innovates
- Canadian Institutes of Health Research