Unilateral Gynecomastia and Primary Hypogonadism Following Brucellosis Infection: A Rare Case Report

Brucellosis is a bacterial infection with a wide spectrum of clinical manifestations, yet endocrine complications such as primary hypogonadism and gynecomastia are exceedingly rare. We present the case of a 60-year-old male who was treated for brucellosis and, several weeks after discharge, developed unilateral enlargement of the left breast. Laboratory evaluation revealed significantly elevated gonadotropins (FSH and LH) with markedly decreased serum testosterone levels, indicating primary testicular failure. Sonographic imaging confirmed gynecomastia with a flame-shaped, irregular mass. This case highlights a rare hormonal sequela of brucellosis and emphasizes the importance of endocrine evaluation in patients who present with atypical manifestations following systemic infections.

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Publication Details

Journal
Clinical Case Reports
Published
2025-09-01
DOI
https://doi.org/10.1002/ccr3.70880
Citations
1
Primary Topic
Brucella: diagnosis, epidemiology, treatment
Type
article
Field-Weighted Citation Impact
2.35
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article

Unilateral Gynecomastia and Primary Hypogonadism Following Brucellosis Infection: A Rare Case Report

Yaghoub Safdari
1 citations
Clinical Case Reports
Brucella: diagnosis, epidemiology, treatment
2.35
article

Unilateral Gynecomastia and Primary Hypogonadism Following Brucellosis Infection: A Rare Case Report

Yaghoub Safdari
article en
1 citations

Abstract

Brucellosis is a bacterial infection with a wide spectrum of clinical manifestations, yet endocrine complications such as primary hypogonadism and gynecomastia are exceedingly rare. We present the case of a 60-year-old male who was treated for brucellosis and, several weeks after discharge, developed unilateral enlargement of the left breast. Laboratory evaluation revealed significantly elevated gonadotropins (FSH and LH) with markedly decreased serum testosterone levels, indicating primary testicular failure. Sonographic imaging confirmed gynecomastia with a flame-shaped, irregular mass. This case highlights a rare hormonal sequela of brucellosis and emphasizes the importance of endocrine evaluation in patients who present with atypical manifestations following systemic infections.

Clinical Case ReportsVol. 13(9)
Golestan University (IR), Golestan University of Medical Sciences (IR)
Openalex Percentile: Top 11%
Brucella: diagnosis, epidemiology, treatment
2.35
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