Targeting CIRP and IL-6R-mediated microglial inflammation to improve outcomes in intracerebral hemorrhage
CIRP plays a pivotal role in post-ICH neuroinflammation by acting on IL-6R in microglia. The TCC peptide inhibitor effectively reduces CIRP-IL-6R mediated inflammation and supports neuroprotection. CIRP represents a promising therapeutic target and biomarker for ICH.
Authors
- Chao Xiang (ORCID: https://orcid.org/0000-0001-6649-681X)
- Lisha Ye (ORCID: https://orcid.org/0000-0002-2184-5374)
- Zheng‐Lin Jiang (ORCID: https://orcid.org/0000-0002-7134-5511)
- Xiaoyu Yuan (ORCID: https://orcid.org/0009-0007-0421-7011)
- Tianjiao Wei (ORCID: https://orcid.org/0000-0003-1546-4257)
- Qianqian Luo (ORCID: https://orcid.org/0000-0001-8302-3117)
- Xiaoyan Tang
- Guohua Wang (ORCID: https://orcid.org/0000-0002-4810-8534)
- Lihua Xu
- Fangming Liu (ORCID: https://orcid.org/0000-0001-9224-961X)
- Jianjun Gu (ORCID: https://orcid.org/0000-0001-9082-9821)
- Ting Xu (ORCID: https://orcid.org/0000-0001-7827-4421)
- Lihua Shen (ORCID: https://orcid.org/0000-0003-4068-8631)
Institutions
- Capital Medical University (CN)
- Nantong University (CN)
- Affiliated Hospital of Nantong University (CN)
- Henan Provincial People's Hospital (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1016/j.jare.2025.09.012
- Citations
- 3
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.53