Mismatch Repair Deficiency in Gliomas: A Rare Insight into Microsatellite Instability and Its Diagnostic Implications
MMR deficiency is rare in gliomas, with isolated MSH6 loss being the most common finding. While not significantly associated with tumor grade or patient demographics, MMRD may have clinical relevance in specific subgroups. NGS findings highlight the potential utility of integrating molecular diagnostics for identifying MSI and guiding immunotherapy decisions.
Authors
- S. K. Arora (ORCID: https://orcid.org/0000-0002-8402-5007)
- Charanjeet Ahluwalia (ORCID: https://orcid.org/0000-0002-1215-0327)
- Sana Ahuja (ORCID: https://orcid.org/0000-0002-4630-016X)
- Kepeemadam Balasubramanyam Shankar
- Indhumathi Rajendiran
Institutions
- Vardhman Mahavir Medical College & Safdarjung Hospital (IN)
Publication Details
- Journal
- Asian Journal of Neurosurgery
- Published
- 2025-09-09
- DOI
- https://doi.org/10.1055/s-0045-1811689
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00