Giant Cell Tumor of the Tendon Sheath

Abstract Giant cell tumor of the tendon sheath (GCT-TS) is a benign, slow-growing lesion originating from the tendon sheath or adjacent bursal tissue. We present a series of four histologically confirmed cases with atypical presentations in the foot and hand. Clinical features included a slow-growing, painless mass, often associated with prior trauma. All patients underwent surgical excision, with histopathology confirming GCT-TS. This report emphasizes the importance of considering GCT-TS in the differential diagnosis of soft-tissue swellings in tendon-rich areas and highlights the role of surgery as definitive management.