Cabozantinib Sensitizes NSCLC Cells to Radiation by Inducing Ferroptosis via STAT3/MCL1/BECN1/SLC7A11 Axis Suppression
Cabozantinib enhances the radiosensitization of NSCLC cells through ferroptosis induction mediated by the suppression of the STAT3/MCL1/BECN1/SLC7A11 axis. These findings uncover a novel mechanism linking kinase inhibition to redox imbalance and suggest that the pharmacologic modulation of ferroptosis using multi-target TKIs may represent a rational approach to overcome radioresistance in NSCLC.
Authors
- Cheng‐Yi Wang (ORCID: https://orcid.org/0000-0001-7426-0743)
- Chao‐Yuan Huang (ORCID: https://orcid.org/0000-0002-9322-6062)
- Li‐Ju Chen (ORCID: https://orcid.org/0000-0002-2085-2046)
- Shiao‐Ya Hong (ORCID: https://orcid.org/0000-0003-4302-1509)
- G. Chen (ORCID: https://orcid.org/0000-0002-8253-2830)
Institutions
- Fu Jen Catholic University (TW)
- National Yang Ming Chiao Tung University (TW)
- National Taiwan University Hospital (TW)
- Cardinal Tien Hospital (TW)
- Taipei Medical University (TW)
Publication Details
- Journal
- Cancers
- Published
- 2025-09-09
- DOI
- https://doi.org/10.3390/cancers17182950
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chang Gung Memorial Hospital
- National Defense Medical College
- Academia Sinica
- Cardinal Tien Hospital
- National Science and Technology Council