Clinical use of xenon-oxygen therapy to restore neuropsychological and adaptive status in young women with hormone-dependent breast cancer after total ovarian suppression

Purpose of the study. The objective of this study is to evaluate the clinical effectiveness of activation xenon-oxygen therapy (XOT) in correcting neuropsychological and adaptive status in patients diagnosed with hormone-dependent breast cancer who have undergone total ovariectomy. Patients and methods. We analyzed data on the intensity of clinical symptoms, the dynamics and intensity of adaptive responses (AR) with calculation of the anti-stress/stress ratio, as well as the bioelectric brain activity of 36 young patients diagnosed with hormone-dependent breast cancer, presenting with clinical signs of post-mastectomy syndrome (PMES) and early signs of post-ovariectomy syndrome (POES). Results. In determining the distribution of stress and anti-stress reactions, a postoperative phase transition from a physiological to a pathological state was reliably established. In the postoperative period following ovariectomy, normal reaction types were observed in 11.3 % of cases. The predominant response was the stress reaction. Analysis of AR structure in patients with PMES and POES manifestations demonstrated a clear advantage for XOT. During rehabilitation, patients in the non-XOT group did not achieve full restoration of AR structure to baseline values, with the stress response persisting in 58.7 % of cases. In contrast, the XOT group demonstrated anti-stress reactions, with no stress reactions detected. Furthermore, analysis of the bioelectric activity of the brain in patients after two hormone-reducing surgeries revealed significant alterations in the spectral power of the electroencephalogram (EEG). These changes were indicative of a balanced state of excitation and inhibition, suggesting an equilibrium in neural processes underlying cognitive function. Conclusion. Xenon, as a biologically active factor, functions as a catalyst for complex functional transformations within the body's regulatory systems. Xenon-based therapy induces a substantial reduction in stress reactions, highlighting the pronounced biotropic effect of xenon in restoring the adaptive status of the female body.