Exploring the Biological and Theoretical Aspects of Rare Earth Metal Mixed Ligand Complexes: A Synergistic Approach

In order to create novel transition metal-based coordination compounds, Schiff bases based on the sulpha drug reacted with various 2-hydroxy-benzaldehyde derivatives. The antibacterial properties and spectroscopic attributes of the synthesized ligands and their heterochelates were extensively examined. The structural characterization of the ligands was accomplished through 1H-NMR, IR, Mass spectrometry, UV-Vis spectroscopy and elemental analysis, while the heterochelates' structures were validated using IR spectroscopy. In vitro evaluations were conducted to assess the activity of the ligands and heterochelates against Gram +ve bacteria (S. aureus, B. subtilis), Gram -ve bacteria (E. coli, P. aeruginosa) and against fungi A. niger. The findings underscore the promising nature of coordination compounds based on transition metals and highlight the necessity of further exploration in this field.