Enriched environment ameliorates neurobehavioral abnormalities, hippocampal inflammation, and synaptic dysfunction in adult male mice exposed to intermittent hypoxia during pregnancy
In offspring mice, PIH induced ALBs and DLBs, cognitive deficits, elevated hippocampal levels of pro-inflammatory cytokines, upregulation of GFAP, Iba1, and NF-κB/NLRP3 pathway-associated molecules, and reduced expression of synaptic plasticity proteins, including GAP-43, PSD-95, and SYN; however, subsequent treatment with an EE effectively reversed these alterations CONCLUSIONS: EE attenuates PIH-induced inflammatory responses in the hippocampus through suppression of the NF-κB/NLRP3 signaling cascade and alleviates synaptic dysfunction caused by PIH.
Authors
- Chongyang Ren (ORCID: https://orcid.org/0000-0001-7058-8864)
- Zhenyu Hu (ORCID: https://orcid.org/0000-0002-8050-8693)
- Ru‐Meng Wei (ORCID: https://orcid.org/0000-0002-9807-2015)
- Fei Hu (ORCID: https://orcid.org/0000-0001-7827-9548)
- Yueming Zhang (ORCID: https://orcid.org/0000-0003-1109-8253)
- Xueyan Li (ORCID: https://orcid.org/0000-0001-9650-2475)
- Gui-Hai Chen (ORCID: https://orcid.org/0009-0007-7471-737X)
- Yu Zhang (ORCID: https://orcid.org/0000-0001-8066-7275)
- Kaixuan Zhang (ORCID: https://orcid.org/0000-0003-1065-0595)
- Shi-Kun Fang
- Wei-Zhong Lun
Institutions
- Anhui Medical University (CN)
- Chaohu Hospital of Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Brain Research Bulletin
- Published
- 2025-09-09
- DOI
- https://doi.org/10.1016/j.brainresbull.2025.111544
- Citations
- 2
- Primary Topic
- Neuroscience of respiration and sleep
- Type
- article
- Field-Weighted Citation Impact
- 1.83