Evaluating the Impact of Ursodeoxycholic Acid on Hepatic Clearance of [ ^99m Tc]Tc-Sestamibi: A Randomized Controlled Trial to Improve Myocardial Perfusion Imaging

A single 300 mg oral dose of UDCA administered 1 h before stress imaging does not significantly improve hepatic clearance of [^99mTc]Tc-sestamibi or enhance M/L ratios. This is likely due to a pharmacokinetically insufficient regimen, as a single dose is unlikely to achieve the necessary biliary concentration for a significant choleretic effect. Future research should focus on alternative interventions or optimized UDCA dosing schedules, such as multiday protocols, combined with advanced imaging techniques like SPECT/CT, to conclusively determine effective strategies for improving MPS image quality.