TRPV1 Suppresses Microglial Inflammatory Activation to Ameliorate Schizophrenia-Associated Behaviors in Maternal Separation Rats
These findings provided novel insights into the role of microglial TRPV1 in schizophrenia pathogenesis, establishing it as an upstream regulator of the CaMKII/NRF2/SIRT3 signaling axis-a pathway not previously linked to TRPV1 in neuroinflammation. Our work identifies microglia-specific TRPV1 modulation as a new therapeutic strategy for schizophrenia, highlighting its therapeutic potential for cognitive and negative symptoms in schizophrenia.
Authors
- Huan Huang (ORCID: https://orcid.org/0000-0003-2071-5954)
- Gaohua Wang (ORCID: https://orcid.org/0000-0002-8947-9921)
- Gavin P. Reynolds (ORCID: https://orcid.org/0000-0001-9026-7726)
- Rui Xu (ORCID: https://orcid.org/0000-0002-6631-9386)
- Zhongchun Liu (ORCID: https://orcid.org/0000-0001-5410-0312)
- Keke Hao
- Fashuai Chen
- Huiling Wang
- Chang Shu (ORCID: https://orcid.org/0000-0002-3730-5102)
- Ying Xiong (ORCID: https://orcid.org/0000-0003-0532-6328)
- Biwen Peng
Institutions
- Wuhan University (CN)
- Nanfang Hospital (CN)
- Hubei Provincial Center for Disease Control and Prevention (CN)
- Renmin Hospital of Wuhan University (CN)
- Hubei Provincial Department of Education (CN)
- Southern Medical University (CN)
- Sheffield Hallam University (GB)
Publication Details
- Journal
- Schizophrenia Bulletin
- Published
- 2025-08-07
- DOI
- https://doi.org/10.1093/schbul/sbaf153
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Health Commission of Hubei Province
- National Natural Science Foundation of China
- Wuhan University
- Renmin Hospital of Wuhan University