Metabolic dysregulation in Alzheimer's disease: A brain metabolomics approach
This is one of the largest untargeted metabolomics studies of human brain tissue. 155 metabolic features, and 36 metabolic pathways were linked to Alzheimer's disease (AD) neuropathology. Of these, 18 unique metabolites were confirmed with level 1 evidence. Glucose and adenosine 5'-diphosphoribose identified as key metabolic alterations in AD.
Authors
- Anke Hüls (ORCID: https://orcid.org/0000-0002-6005-417X)
- Allan I. Levey (ORCID: https://orcid.org/0000-0002-3153-502X)
- Emma Casey (ORCID: https://orcid.org/0009-0006-4303-4755)
- Youran Tan (ORCID: https://orcid.org/0000-0002-9955-8324)
- Donghai Liang (ORCID: https://orcid.org/0000-0001-7311-2298)
- Marla Gearing (ORCID: https://orcid.org/0000-0002-1959-7412)
- Aliza P. Wingo (ORCID: https://orcid.org/0000-0002-6360-6726)
- Zhenjiang Li (ORCID: https://orcid.org/0000-0002-4806-6231)
- Thomas S. Wingo (ORCID: https://orcid.org/0000-0002-7679-6282)
- Dean P. Jones
- James J. Lah (ORCID: https://orcid.org/0000-0002-8810-620X)
- Douglas I Walker
Institutions
- Emory University (US)
- Northern California Research (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- VA Northern California Health Care System (US)
- University of California, Davis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/alz.70528
- Citations
- 2
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- Emory University
- Goizueta Business School, Emory University
- National Institute on Aging
- National Institute of Environmental Health Sciences