SMARCA2 Deficiency While Preserving SMARCA4 in Lung Adenocarcinoma Combined with Abnormal β-Catenin Expression
SMARCA2-deficient with SMARCA4-preserved lung adenocarcinomas demonstrate substantial histological heterogeneity and may dedifferentiate into high-grade adenocarcinomas harboring TP53 mutations. In the assessment of poorly differentiated lung adenocarcinoma, immunohistochemical detection can identify this subtype for more precise clinical treatment strategies.
Authors
- Xiaoyue Feng (ORCID: https://orcid.org/0000-0002-7177-018X)
- Xiaomin Dai (ORCID: https://orcid.org/0000-0001-8833-8521)
- Jing Li (ORCID: https://orcid.org/0000-0002-6860-6135)
- Fang Peng (ORCID: https://orcid.org/0000-0002-8567-2652)
Institutions
- Zhejiang Hospital (CN)
Publication Details
- Journal
- Cancer Management and Research
- Published
- 2025-09-01
- DOI
- https://doi.org/10.2147/cmar.s533790
- Primary Topic
- Chromatin Remodeling and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00