Evaluation of High-Throughput Gene Chip Array for Enhanced Diagnosis of Bone and Joint Infections: A Comparative Analysis with mNGS and Conventional Culture Methods
HT gene chip assay demonstrates superior diagnostic specificity and cost-effectiveness with rapid turnaround, significantly reducing unnecessary invasive procedures while maintaining high concordance with mNGS, and exhibited higher clinical value of BJI diagnosis compared with mNGS and conventional culture.
Authors
- Yunjiao Zhang (ORCID: https://orcid.org/0000-0002-6465-7488)
- Qingxin Guo (ORCID: https://orcid.org/0000-0002-3703-2394)
- Pei Han (ORCID: https://orcid.org/0000-0002-3347-7900)
- Xiaohua Chen
- Yi Zhang (ORCID: https://orcid.org/0000-0002-9319-4806)
- Jinmei Chen (ORCID: https://orcid.org/0000-0003-0981-760X)
- Yuan Fang (ORCID: https://orcid.org/0009-0004-7278-6740)
- Hao Shen
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Genon Biological Products (China) (CN)
- Shanghai Sixth People's Hospital (CN)
Publication Details
- Journal
- Infection and Drug Resistance
- Published
- 2025-09-01
- DOI
- https://doi.org/10.2147/idr.s523306
- Primary Topic
- Orthopedic Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality
- Shanghai Hospital Development Center