Evaluation of Alkaloidal Extract of Crinum asiaticum as a Potential Therapeutic for Polycycstic Ovarian Syndrome

Polycystic Ovary Syndrome (PCOS) is a multifactorial endocrine disorder affecting approximately 6-20% of women of reproductive age worldwide, depending on diagnostic criteria.Characterized by hyperandrogenism, chronic anovulation, and polycystic ovarian morphology, PCOS is a leading cause of infertility and metabolic dysfunction in women.The etiology of PCOS remains incompletely understood, but it is widely recognized as a complex interplay of genetic, hormonal, and environmental factors.At the molecular level, PCOS is associated with dysregulation of the hypothalamic-pituitary-ovarian (HPO) axis, insulin resistance, and chronic low-grade inflammation.These pathophysiological features contribute to a spectrum of clinical manifestations, including menstrual irregularities, hirsutism, acne, obesity, and increased risk of type 2 diabetes mellitus and cardiovascular disease.Emerging evidence also implicates altered steroidogenesis, adipokine signaling, and oxidative stress in the progression of PCOS, highlighting the need for integrative approaches to its study.Despite its prevalence and impact, therapeutic options for PCOS remain limited and largely symptomatic.Current treatments focus on lifestyle modification, insulin sensitizers, and hormonal regulation, yet they often fail to address the underlying biological mechanisms.Consequently, there is growing interest in exploring novel compounds, cellbased assays, and targeted interventions to elucidate and modulate the molecular pathways involved in PCOS pathogenesis.This article aims to investigate the efficacy of alkaloidal extract of Crinum asiaticum against PCOS, owing to the effect of plant extract in controlling menstrual bleeding and other effects on female reproductive system.This study will cater the need to find an alternative or supplementary therapeutics for PCOS and paving the way for more effective therapeutic strategies.