Enhanced Skin Permeation and Pigmentation Reduction Effects of a Novel Tranexamic Acid‐Mandelic Acid Ion‐Pairing Complex
This study successfully formed a TXA-MA complex. Compared to TXA, the TXA-MA complex showed superior effects in skin permeability, inhibition of inflammatory marker expression, and actual skin pigmentation reduction. These results suggest that the TXA-MA complex holds greater potential as an effective cosmetic ingredient for pigmentation improvement than TXA alone.
Authors
- Eun‐Jung Choi (ORCID: https://orcid.org/0000-0002-3518-6859)
- Nojin Park
- Kyoungin Min
- Hyungjoon Jeon (ORCID: https://orcid.org/0000-0001-7461-0969)
- Chang Kyu Kim
- Sang‐Wook Park
- Ji‐Won Choi (ORCID: https://orcid.org/0000-0002-7701-3227)
- Jong Gu Won
- Nam Seo Son
- Yong Won Shin
Institutions
- LG (United States) (US)
Publication Details
- Journal
- Skin Research and Technology
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1111/srt.70222
- Primary Topic
- melanin and skin pigmentation
- Type
- article
- Field-Weighted Citation Impact
- 0.00