Histologic Follow-Up of Endometrial Gland Crowding Shows Progression to Hyperplasia

In order to assess the risk of pre-malignant or malignant lesions in women with gland crowding on endometrial samples when full histologic criteria for endometrial hyperplasia are not met, we evaluated gland crowding incidence and follow-up samples in ambulatory gynecology clinics at Sligo University Hospital.Our results show that up to 20% of women with gland crowding may have a more sinister pre-malignant lesion on 6-12-month follow-up sampling.Identification of gland crowding on pipelle and curettage endometrial samples may help prevent endometrial cancer in these patients.