An Update of Bioactive Compounds for Therapy of Metabolic Dysfunction-Associated Steatosis Liver Disease (MASLD) -- A Short Communication

Having reviewed the different significant etiopathogenesis and role of Vitamin D/its Receptor and Allyl Isothiocyanate (AITC)", with Prospective Therapies Like L-Carnitine (LC), Nicotinamide Ribose (NR) Combination, as well as Apical Sodium Dependent Bile Acids Transporter (ASBT) or Volixibat and Silybin, probiotics, prebiotics, and synbiotics., role of Resveratrol's Effects, natural products in the treatment of diabesity, inclusive of polyphenols along with flavonoids, dietary polyphenols, like resveratrol, curcumin, proteintyrosine phosphatase1 B ( PTP1B) inhibitors, plant terpenes (specifically monoterpenes), flavonoids (querceetin, kaempherol), ursolic acid, besides epigenetic modes of certain plant agents antidiabetic action, like nonflavonoid polyphenols like curcumin, tannins, lignans as well as resveratrol, or flavonoids like anthrocyanins, epigallocatechin gallate (EGCG), quercetin, naringin, rutin along with kaempherol, astragaloside IV and other prospective agents, knowledge of Hepatic Macrophages and association of dietary fatty acids and gut microbiota alterations with Gut-Liver Axis with Gut Microbiome Dysbiosis correlated non alcoholic fatty Acid liver disease (NAFLD) along with non alcoholic steatohepapititis ( NASH) alias metabolic dysfunction-associated steatosis liver disease (MASLD, alias NAFLD earlier) or MASH now, Curcumin Actions, role ofi) Obeticholic acid (OCA; Farsenoid X receptor [FXR] agonist) ii) Elafibranor (a Peroxisome Proliferator Activated Receptor [PPAR ] as well as agonist) iii) cenicriviroc (CVC-a dual antagonist of C-C chemokine receptor (cenicriviroc CCR) types 2 as well as 5 iv) resmetriom (THR--agonist) as well as aramchol (stearoyl-Co A desaturase [SCD1 inhibitor Yet no clearcut answer is there for therapy of, NAFLD,NASH metabolic dysfunction-associated steatosis liver disease (MAFLD), MASH.Herewe further detail, which herbal, plant products evaluated might work in therapy of such disorder.Other than silymarin, curcumin and probiotics, prebiotics, and synbiotics not much efficacy was seen with other bioactive compounds evaluated globally.