Genetic heterogeneity in childhood leukemia/lymphoma: a Turkish cohort with strong predisposition
These findings emphasize the clinical utility of germline testing in pediatric hematologic cancers by providing novel insights into the predisposition to leukemia/lymphoma and contributing to treatment regimens, donor selection, and diagnostic refinement, particularly in populations with high consanguinity.
Authors
- Sezer Akyoney (ORCID: https://orcid.org/0000-0003-2514-4142)
- Müge Sayitoğlu (ORCID: https://orcid.org/0000-0002-8648-213X)
- Elif İnce (ORCID: https://orcid.org/0000-0002-6846-6048)
- Fatih Erbey (ORCID: https://orcid.org/0000-0002-4475-0407)
- Özlem Akgün Doğan (ORCID: https://orcid.org/0000-0002-8310-4053)
- Fulya Taylan (ORCID: https://orcid.org/0000-0002-2907-0235)
- Yunus Murat Akçabelen
- Ufuk Amanvermez (ORCID: https://orcid.org/0000-0003-1037-6477)
- Busra Unal (ORCID: https://orcid.org/0000-0002-2056-2604)
- Uğur Özbek (ORCID: https://orcid.org/0000-0001-5319-0547)
- Uğur Demırsoy (ORCID: https://orcid.org/0000-0002-5424-7215)
- Banu Oflaz Sözmen (ORCID: https://orcid.org/0000-0001-7212-7041)
- Davut Albayrak (ORCID: https://orcid.org/0000-0002-7947-3817)
- Dilek Kaçar (ORCID: https://orcid.org/0000-0003-0825-8316)
- Ömer Doğru (ORCID: https://orcid.org/0000-0002-2528-2409)
- İkbal Ok Bozkaya (ORCID: https://orcid.org/0000-0002-7666-8731)
- Neşe Yaralı (ORCID: https://orcid.org/0000-0001-5488-2385)
- Fikret Asarcıklı (ORCID: https://orcid.org/0000-0002-2879-6827)
- Özkan Özdemir (ORCID: https://orcid.org/0000-0002-2647-6416)
- Nihat Buğra Ağaoğlu (ORCID: https://orcid.org/0000-0002-9336-0552)
- Özden Hatırnaz Ng (ORCID: https://orcid.org/0000-0001-7728-6527)
- Koray Yalçın (ORCID: https://orcid.org/0000-0003-3454-9870)
- Turan Bayhan (ORCID: https://orcid.org/0000-0001-5793-5606)
- Seda Aras (ORCID: https://orcid.org/0000-0001-9000-9014)
- Ann Nordgren (ORCID: https://orcid.org/0000-0003-3285-4281)
- Namık Yaşar Özbek (ORCID: https://orcid.org/0000-0001-6857-0681)
- Nihal Özdemir (ORCID: https://orcid.org/0000-0002-3204-4353)
- Gizem Önder (ORCID: https://orcid.org/0000-0003-4933-8048)
- Alper Akkus (ORCID: https://orcid.org/0009-0005-8696-0284)
- Eylul Aydin (ORCID: https://orcid.org/0009-0005-3982-5303)
- Berk Ergun (ORCID: https://orcid.org/0009-0007-0299-5549)
- Cengiz Canpolat
Institutions
- Bahçeşehir University (TR)
- Universidade Federal do Acre (BR)
- Izmir University (TR)
- Karolinska University Hospital (SE)
- Koç University (TR)
- Ankara University (TR)
- Dokuz Eylül University (TR)
- Sahlgrenska University Hospital (SE)
- Karolinska Institutet (SE)
- Memorial Ankara Hospital (TR)
- Biruni University (TR)
- HUN-REN Institute of Experimental Medicine (HU)
- Ümraniye Eğitim ve Araştırma Hastanesi (TR)
- Samsun University (TR)
- Istinye University (TR)
- Health Information Management (BE)
- Başkent University Hospital (TR)
- Krankenhaus Nordwest (DE)
- Kent Hastanesi (TR)
- GATA Haydarpaşa Eğitim Hastanesi (TR)
- Kocaeli Üniversitesi (TR)
- Istanbul University (TR)
- University of Gothenburg (SE)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-09-09
- DOI
- https://doi.org/10.3389/fgene.2025.1624306
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Karolinska Institutet
- Türkiye Bilimsel ve Teknolojik Araştırma Kurumu
- Türk Hematoloji Derneği