Integrative RNA-seq and CLIP-seq analysis reveals hnRNP-F regulation of TNFα/NFκB signaling in high-glucose conditions
<i>hnRNP-F</i> has dual functions in mRNA transcriptional and post-transcriptional levels and may bind with lncRNA <i>SNHG1</i> to negatively regulate the transcription of genes involved in the <i>TNFα/NFκB</i> signaling pathway. Meanwhile, <i>hnRNP-F</i> may function in the co-regulation of alternative splicing events in cells by interacting with ZFP36 to form a complex.
Authors
- Lan Wang (ORCID: https://orcid.org/0000-0001-7701-2219)
- Huimeng Li
- Xinyu Guo (ORCID: https://orcid.org/0000-0001-9550-0769)
- Xiaoqin Wang (ORCID: https://orcid.org/0000-0002-8849-8119)
Institutions
- Hubei University of Chinese Medicine (CN)
- Hubei Provincial Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2025-09-09
- DOI
- https://doi.org/10.3389/fphys.2025.1475441
- Primary Topic
- GDF15 and Related Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00