Tcirg1 deficiency delays osteoarthritis progression by impairing lysosome acidification and peripheral accumulation in osteoclasts
Tcirg1 regulates lysosome acidification and peripheral accumulation, thereby influencing osteoclast activity in the subchondral bone. Given that <i>Tcirg1</i> knockdown was found to slow down the progression of OA, targeting Tcirg1 may serve as a potential therapeutic strategy for treating OA.
Authors
- Qunhua Jin (ORCID: https://orcid.org/0000-0001-7616-3357)
- Qi Ma (ORCID: https://orcid.org/0000-0001-9925-6492)
- Yajing Su (ORCID: https://orcid.org/0000-0003-0454-1405)
- Jiangbo Yan (ORCID: https://orcid.org/0000-0001-5019-346X)
- Zhibin Lan (ORCID: https://orcid.org/0000-0001-8610-7244)
- Xiaoxin He (ORCID: https://orcid.org/0009-0005-3590-0302)
- Yang Yang (ORCID: https://orcid.org/0000-0002-4694-685X)
- Xin Zhao (ORCID: https://orcid.org/0000-0002-4577-5622)
- Zhirong Chen (ORCID: https://orcid.org/0009-0001-7039-7707)
- Long Ma (ORCID: https://orcid.org/0000-0003-2793-4754)
- Sun Rui (ORCID: https://orcid.org/0000-0003-3742-0159)
- Ye Ma (ORCID: https://orcid.org/0000-0003-2163-1285)
- Gang Wu (ORCID: https://orcid.org/0000-0001-9401-0549)
- Di Xue
- Xue Lin
- Kuanmin Tian
- Zhaopu Tuo
Institutions
- Ningxia Medical University (CN)
- Ningxia Medical University General Hospital (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-09-09
- DOI
- https://doi.org/10.3389/fcell.2025.1621648
- Citations
- 3
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.42