Association of gut microbiota dysbiosis with non-alcoholic fatty liver disease: A cross-sectional study

The association between gut microbiota dysbiosis and non-alcoholic fatty liver disease (NAFLD) in 132 adults were diagnosed using ultrasonography. Stool samples were analyzed using 16S rRNA sequencing to assess microbiota composition. Patients with NAFLD showed a significant decrease in <i>Bacteroidetes</i> and an increase in <i>Firmicutes</i> and <i>Proteobacteria</i> compared to controls. Altered microbial diversity correlated with elevated liver enzymes and insulin resistance markers. Data shows that gut microbiota imbalance plays a contributory role in the pathogenesis of NAFLD.