Lugol's iodine-guided excision margin determination in oral mucosal lesion management

Lugol's iodine (LI) is recognized for its diagnostic efficacy in identifying and delineating sufficient margins of the biopsy region. Therefore, it is of interest to evaluate the variance in excision margins between visual assessment and LI as well as to histopathologically analyze the disease-free margin post-excision. The diameters of the lesions were statistically compared before and after the application of LI in 18 male patients. The histopathological report was assessed for disease-free margins. Data shows that LI stain is an essential method for assessing the progression/excision margins of suspicious oral lesions, hence aiding in the early identification of oral cancer.