Shatai Heji Mitigates Sjögren Disease-Induced Xerostomia by Regulating AQP5, NF-κB, and p38 MAPK Signaling Pathwaysaff
This is the first study to establish quality control standards for STHJ and to demonstrate its anti-inflammatory and immunomodulatory effects in xerostomia models. The findings suggest that STHJ may serve as a safe and effective therapeutic option for xerostomia associated with SjD and other conditions.
Authors
- Jiyuan Chen (ORCID: https://orcid.org/0000-0001-6195-4738)
- Gang Yang (ORCID: https://orcid.org/0000-0001-6524-9710)
- Rong Wang (ORCID: https://orcid.org/0000-0002-2649-1472)
- Chunai Gong (ORCID: https://orcid.org/0000-0002-6707-5547)
- Minyan Chen
- Ru Yao (ORCID: https://orcid.org/0000-0003-2863-6919)
- Shengnan Li (ORCID: https://orcid.org/0000-0003-1111-5981)
- Yongfang Yuan (ORCID: https://orcid.org/0000-0003-4093-8725)
- Chun Chen (ORCID: https://orcid.org/0000-0001-9772-2728)
- Fangbin Liu
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Ninth People's Hospital (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-09-01
- DOI
- https://doi.org/10.2147/dddt.s526278
- Primary Topic
- Salivary Gland Disorders and Functions
- Type
- article
- Field-Weighted Citation Impact
- 0.00