Synergistic Anticancer Effects of Lenvatinib and Celastrol via ROS-Mediated ER Stress and JNK Signaling in Colon Cancer Cells
Our research demonstrates that celastrol potentiates lenvatinib's anti-tumor effects in colon cancer by inducing ROS-dependent ER stress and triggering phosphorylation-dependent JNK pathway activation. These findings revealing a promising combinatorial strategy to enhance therapeutic efficacy in colorectal carcinoma.
Authors
- Yunzhi Chen (ORCID: https://orcid.org/0000-0002-1590-4796)
- Ri Cui (ORCID: https://orcid.org/0000-0001-6202-8779)
- Wenying Fu
- Jundixia Chen (ORCID: https://orcid.org/0009-0008-7749-9547)
- Chenyang Qiu
- Yan Yan (ORCID: https://orcid.org/0000-0002-5917-1475)
- Chenxin Xu (ORCID: https://orcid.org/0009-0008-2799-8508)
- Peng Zou (ORCID: https://orcid.org/0000-0003-1498-842X)
- Yinghua Chen (ORCID: https://orcid.org/0000-0003-2295-7228)
- Yiqun Xia
- Duojiao Ni
- Chih-Hung Shu
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Yueqing People's Hospital (CN)
Publication Details
- Journal
- Cancer Research and Treatment
- Published
- 2025-09-09
- DOI
- https://doi.org/10.4143/crt.2025.508
- Primary Topic
- Natural Compounds in Disease Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Zhejiang Province