Large extracellular vesicles derived from LPS-preconditioned cardiomyocytes alleviate myocarditis via mediating macrophage polarization and modulating p38 MAPK pathway
This study highlights the effect of C-lEV<sub>LPS</sub> in myocarditis and uncovers the potential mechanism that modulates macrophage polarization by delivering PP2AA from cardiomyocytes to macrophages and regulating the p38 MAPK pathway. These findings provide a promising therapeutic strategy for myocarditis.
Authors
- Shan Zhou (ORCID: https://orcid.org/0000-0001-9067-6802)
- Yaxue Xie
- Bo Han (ORCID: https://orcid.org/0000-0002-4798-7725)
- Yanjie Jiang (ORCID: https://orcid.org/0000-0001-6404-9143)
- Yingnan You (ORCID: https://orcid.org/0009-0005-5139-2977)
- Mengjie Ma (ORCID: https://orcid.org/0000-0001-8450-3286)
Institutions
- Shandong University (CN)
- Shandong Provincial Hospital (CN)
- Taian City Central Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-09
- DOI
- https://doi.org/10.3389/fimmu.2025.1629676
- Citations
- 1
- Primary Topic
- Viral Infections and Immunology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.39