Analysis of T Cell Subsets Using Multiplex Immunohistochemistry and Clinical Outcomes of Immune Checkpoint Inhibitors in Advanced Gastric Cancer Patients
T-cell subsets within the tumor microenvironment were associated with the clinical efficacy of ICIs in GC. PD-1- or TIM-3 expressing T-cells were also associated with response to ICIs, while memory T-cells subsets were associated with survival. mIHC is a feasible method for evaluating T-cell subsets in archival gastric tumor tissue.
Authors
- Yoonjin Kwak (ORCID: https://orcid.org/0000-0001-5314-2465)
- Dae-Won Lee
- Hye Seung Lee (ORCID: https://orcid.org/0000-0002-1667-7986)
- Tae-Yong Kim (ORCID: https://orcid.org/0000-0002-4147-3635)
- Jeesun Yoon (ORCID: https://orcid.org/0000-0002-1456-2392)
- Do-Youn Oh
Institutions
- Seoul National University (KR)
- Seoul National University Hospital (KR)
Publication Details
- Journal
- Cancer Research and Treatment
- Published
- 2025-09-09
- DOI
- https://doi.org/10.4143/crt.2025.458
- Primary Topic
- Gastrointestinal Tumor Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Seoul National University