Prognostic value of radiological and pathological complete response following immune-based conversion therapy in patients with unresectable hepatocellular carcinoma (GUIDANCE004)
It is unclear whether radiological and pathological complete responses after immune-based conversion therapy are associated with each other and with the prognosis of patients with initially unresectable hepatocellular carcinoma. This large-scale retrospective study demonstrates a strong correlation between radiographic and pathologic complete responses, both of which are associated with significantly improved survival outcomes. These findings provide valuable clinical insights, indicating that radiological and pathological complete responses may serve as reliable prognostic indicators following immune-based conversion therapy in this patient population. Furthermore, these response metrics could be used to identify patients most likely to benefit from such therapeutic approaches.
Authors
- Shuchang Chen (ORCID: https://orcid.org/0000-0001-8374-2672)
- Hongbing Yao (ORCID: https://orcid.org/0000-0002-9177-1251)
- Yongrong Lai (ORCID: https://orcid.org/0000-0002-0371-1719)
- Qingqing Pang
- Yong-Rong Liang
- Xueyao Wang (ORCID: https://orcid.org/0009-0009-9386-0088)
- Jia‐Yong Su (ORCID: https://orcid.org/0000-0002-0960-5394)
- Ming-Song Wu (ORCID: https://orcid.org/0000-0001-8513-0637)
- Dalong Yang (ORCID: https://orcid.org/0000-0003-0090-2277)
- Yihe Yan (ORCID: https://orcid.org/0000-0002-3387-2273)
- Jingying Nong (ORCID: https://orcid.org/0000-0002-0682-2190)
- Ze Su (ORCID: https://orcid.org/0009-0000-1360-0783)
- Fan-Jian Zeng
- Yihua Chen (ORCID: https://orcid.org/0000-0003-1733-7980)
- Jian‐Hong Zhong (ORCID: https://orcid.org/0000-0002-1494-6396)
- Fu-Xin Li
- Ning Peng (ORCID: https://orcid.org/0000-0003-4213-1159)
- Shen Huang (ORCID: https://orcid.org/0000-0002-8827-4086)
- Mian-Jing Li
- Wenfeng Li (ORCID: https://orcid.org/0000-0002-3250-3062)
- Fuquan Yang (ORCID: https://orcid.org/0000-0002-2841-5342)
- Shaoping Liu
- Chuang Qin (ORCID: https://orcid.org/0000-0002-7296-914X)
- Teng-Meng Zhong
- Min Luo (ORCID: https://orcid.org/0009-0001-1101-1675)
- Huan Chen (ORCID: https://orcid.org/0000-0002-6487-7923)
- Kang Chen (ORCID: https://orcid.org/0000-0002-9494-2685)
- Jie Liu (ORCID: https://orcid.org/0000-0002-0373-2827)
- Xiumei Liang
- Xiao-Feng Dong
- Liang Ma (ORCID: https://orcid.org/0000-0001-8106-373X)
- Yingyu Zhang (ORCID: https://orcid.org/0000-0002-6507-8867)
- Lin Ye
- Yong‐Yu Yang
- Yi-Ge Zhang
- Pei‐Sheng Wu
- Zhicheng Li
- Yaqun Yu (ORCID: https://orcid.org/0000-0001-9415-8375)
- X H Mao
- Jun‐Jie Ou (ORCID: https://orcid.org/0009-0003-2700-1118)
- Sicong Lu
- Yi-Li Ma
- Guo‐Dong Wang (ORCID: https://orcid.org/0000-0001-6574-1668)
Institutions
- Guangxi Medical University (CN)
- Hengshui University (CN)
- Guilin Medical University (CN)
- Beihai People's Hospital (CN)
- Liuzhou Maternal and Child Health Hospital (CN)
- Liuzhou General Hospital (CN)
- Beibu Gulf University (CN)
- The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine (CN)
- Wuzhou University (CN)
- The People's Hospital of Guangxi Zhuang Autonomous Region (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- The Second Nanning People's Hospital (CN)
- Baise University (CN)
- Affiliated Hospital of Guilin Medical College (CN)
- First People's Hospital of Nanning (CN)
- Hezhou University (CN)
- Wuzhou Red Cross Hospital (CN)
- Yulin University (CN)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-09-09
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101587
- Citations
- 4
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 5.29
Funders
- National Natural Science Foundation of China
- Guangxi Medical University
- Guangxi University
- Guilin Medical University
- Guangxi Key Research and Development Program
- Division of Graduate Education