Effect of Pemafibrate on Metabolic Dysfunction‐Associated Steatotic Liver Disease: A Nationwide Multicenter Study
Pemafibrate treatment significantly improved ALT levels and ALT normalization rates in MASLD patients with hypertriglyceridemia, with improvement observed at three months and a sustained effect up to 12 months. This is a large-scale multicenter study to date evaluating pemafibrate in MASLD, providing robust evidence for its potential as a therapeutic option in this population.
Authors
- Masayuki Kurosaki
- Kaoru Tsuchiya (ORCID: https://orcid.org/0000-0003-0436-5915)
- Takehiro Akahane (ORCID: https://orcid.org/0000-0001-8667-2120)
- Toshie Mashiba (ORCID: https://orcid.org/0000-0002-4377-4829)
- Yasushi Uchida (ORCID: https://orcid.org/0000-0002-7998-2427)
- Nobuharu Tamaki (ORCID: https://orcid.org/0000-0003-4634-6616)
- Keiji Tsuji (ORCID: https://orcid.org/0000-0003-4000-835X)
- Hideo Yoshida
- Haruhiko Kobashi (ORCID: https://orcid.org/0000-0003-4313-6808)
- Chikara Ogawa (ORCID: https://orcid.org/0000-0002-4534-6692)
- Namiki Izumi (ORCID: https://orcid.org/0000-0002-0055-8229)
- Hironori Ochi
- Yasuyuki Komiyama
- Hideki Fujii (ORCID: https://orcid.org/0000-0003-1267-9623)
- Michiko Nonogi (ORCID: https://orcid.org/0000-0002-8337-4846)
- Toyotaka Kasai (ORCID: https://orcid.org/0000-0003-0753-3347)
- Hirotaka Arai (ORCID: https://orcid.org/0000-0003-1119-8588)
- Nami Mori
- Masahiko Kondo (ORCID: https://orcid.org/0000-0003-0435-4909)
Institutions
- Takamatsu Red Cross Hospital (JP)
- Maebashi Red Cross Hospital (JP)
- Japanese Red Cross Medical Center (JP)
- Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital (JP)
- Okayama Red Cross General Hospital (JP)
- Matsuyama Red Cross Hospital (JP)
- Kyoto first Red Cross hospital (JP)
- Tokushima Red Cross Hospital (JP)
- Matsue Red Cross Hospital (JP)
- Otsu Red Cross Hospital (JP)
- Musashino Red Cross Hospital (JP)
- Saitama Red Cross Hospital (JP)
Publication Details
- Journal
- JGH Open
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/jgh3.70277
- Citations
- 2
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- Japan Agency for Medical Research and Development
- Ministry of Health, Labour and Welfare