An economic analysis of BPaL for multidrug-resistant TB in South Africa and the Philippines
BPaL-based regimens reduce cost per successful treatment compared with SSOR and require smaller budgets for similar treatment outcomes. Implementation may involve initial budget increases, but improvements in treatment success and long-term health outcomes outweigh these costs, presenting a strong rationale for rollout.
Authors
- Amanda Mabhula
- Surender Juneja (ORCID: https://orcid.org/0000-0002-2771-8827)
- Norbert Ndjeka (ORCID: https://orcid.org/0000-0001-6200-1592)
- Maria Tarcela Gler
- Kamban Hirasen (ORCID: https://orcid.org/0000-0001-9531-9230)
- Dessa Jean O. Casalme
- Lindi M. Coetzee (ORCID: https://orcid.org/0000-0002-8981-1744)
- Sithabiso Masuku (ORCID: https://orcid.org/0000-0001-7062-6322)
- Cornelius Nattey (ORCID: https://orcid.org/0000-0002-8272-9529)
- Denise Evans (ORCID: https://orcid.org/0000-0003-0698-1228)
- Amitesh Gupta (ORCID: https://orcid.org/0000-0002-4538-6926)
- Brooke E Nichols (ORCID: https://orcid.org/0000-0003-4682-4999)
Institutions
- National Health Laboratory Service (ZA)
- Boston University (US)
- University of Cape Town (ZA)
- University of the Witwatersrand (ZA)
- TB Alliance (US)
- Clinical Innovations (United States) (US)
- Amsterdam Institute for Global Health and Development (NL)
- Department of Health (ZA)
- Amsterdam University Medical Centers (NL)
- De La Salle University (PH)
- University of Amsterdam (NL)
- University of Sheffield (GB)
Publication Details
- Journal
- IJTLD OPEN
- Published
- 2025-09-01
- DOI
- https://doi.org/10.5588/ijtldopen.25.0294
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- United States Agency for International Development
- Bill and Melinda Gates Foundation
- Vanderbilt University
- Irish Aid
- Bloomberg Philanthropies
- Centers for Disease Control and Prevention Foundation
- Vital Strategies
- Department of Foreign Affairs and Trade, Australian Government
- Bundesministerium für Bildung und Forschung
- Korea International Cooperation Agency
- Foreign, Commonwealth and Development Office
- Centers for Disease Control and Prevention