Lipid profile abnormalities in migraine patients: A cross-sectional study

Background. Migraine is a common neurological disorder characterized by moderate-to-severe headaches lasting 4 to 72 hours. Dyslipidemia has been suggested as a risk factor for migraine and may increase the risk of coronary vascular disease. Given the high prevalence of migraine in India, further investigation into lipid profiles among migraine patients is warranted. This study aims to explore lipid profile differences in patients with migraine, focusing on those with and without aura. Methods. This cross-sectional study included 50 migraine patients of both sexes. Demographic and clinical data, including age, sex, body mass index (BMI), migraine type, aura presence, and duration, were collected. Lipid profiles measured included low-density lipoprotein (LDL), high-density lipoprotein (HDL), serum triglycerides, and total cholesterol. Results. Among 50 patients, females predominated, and most were aged 21–50 years with normal BMI (64%). Migraines with aura accounted for 72%, while 28% had migraines without aura. Lipid profiles significantly differed between groups: patients with aura had elevated total cholesterol and triglycerides, along with normal HDL levels. In contrast, patients without aura exhibited lower HDL and very-low-density lipoprotein (VLDL) levels. LDL levels did not differ significantly between the groups. Conclusion. The study demonstrates a significant association between lipid profile abnormalities and migraine types, with elevated total cholesterol and triglycerides and lower HDL more common in patients with migraine with aura. These findings suggest lipid profile assessment may be relevant in the clinical evaluation of migraine patients.