Advanced Glycation End Products Induce Caudal Disc Degeneration in Ovariectomized Female Rats
A single injection of AGEs to caudal discs can cause reliable and reproducible IVDD in ovariectomized female rats. Additionally, the endogenous estrogen might have a protective effect on the IVD to mitigate the degeneration.
Authors
- Xiaoming Tian
- Liang Xiao (ORCID: https://orcid.org/0000-0003-0836-4397)
- Ze Gao
- Sidong Yang (ORCID: https://orcid.org/0000-0003-2342-4714)
- Justin John Cooper-White (ORCID: https://orcid.org/0000-0002-1920-8229)
- Pengcheng Ren (ORCID: https://orcid.org/0000-0002-3219-8125)
- Wei Zhang
- Zhaohui Li (ORCID: https://orcid.org/0000-0002-4132-658X)
- Guobin Liu (ORCID: https://orcid.org/0000-0002-2968-240X)
Institutions
- Hebei Medical University (CN)
- The University of Queensland (AU)
- Tianjin First Center Hospital (CN)
- Third Hospital of Hebei Medical University (CN)
- Hebei General Hospital (CN)
- Tianjin People's Hospital (CN)
- Spinal Research (GB)
- Beijing Shijitan Hospital (CN)
- First Affiliated Hospital of Hebei Medical University (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- JOR Spine
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/jsp2.70114
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Department of Education of Hebei Province
- Natural Science Foundation of Hebei Province
- Horizon 2020 Framework Programme