Topical Delivery of Calcium Silicate for Nail Health: A Clinical and Experimental Evaluation

Silicon (Si) plays a crucial role in maintaining the structural integrity of nails, skin, and hair by supporting collagen synthesis and keratin stability. Despite its recognized benefits, effective topical delivery methods remain underexplored. This study investigates a novel approach using a calcium silicate-based formulation designed to enhance silicon bioavailability. The research comprises two key components: an in vitro assessment of calcium silicate dissolution and ion release, and a 28-day, single-arm, clinical evaluation of its effects on nail thickness and strength. Ion release studies demonstrated stable dissolution with significant silicon and calcium release. In the clinical study, the mean nail thickness score increased from 1.50 ± 0.51 to 2.09 ± 0.53, corresponding to a 39% mean improvement and nail strength scores improved from 1.50 ± 0.51 to 2.45 ± 0.67, reflecting a 64% average increase over 28 days of application (p < 0.001). The findings support the potential of targeted silicon delivery systems in cosmetic applications, offering an alternative to traditional oral supplementation.