Angiotensin-(1-7) Inhibits Angiogenesis and Alleviates Joint Damage in CIA Mice via the Hippo–YAP Pathway
Ang-(1-7) acts on the Mas receptor to regulate Hippo-YAP signaling, inhibit YAP activation, and suppress the production of HIF-1, VEGF and VEGFR2. This leads to the suppression of TNF-α-stimulated HUVEC activity, thereby attenuating synovial angiogenesis, inflammation, and joint damage in CIA mice.
Authors
- Feifeng Ren
- Yichen Zhang
- Dan Yu (ORCID: https://orcid.org/0000-0002-7488-9004)
- Lin Tang (ORCID: https://orcid.org/0000-0002-6406-9563)
- Wenhan Huang (ORCID: https://orcid.org/0000-0002-3267-5593)
- Min Sheng (ORCID: https://orcid.org/0000-0002-2307-8607)
- Kechen Qian
- Shan Zhang (ORCID: https://orcid.org/0009-0002-0732-7025)
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-09-01
- DOI
- https://doi.org/10.2147/jir.s534282
- Citations
- 2
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 2.30