Primed Extracellular Vesicles as a Nanotherapeutic Strategy to Enhance Granulosa Cell Function in a Model of Premature Ovarian Insufficiency and Hormonal Decline
Primed AMSC-sEVs offer a promising nanotherapeutic strategy to restore ovarian cell function in POI-like conditions via enhanced anti-apoptotic and steroidogenic effects. These findings support the translational potential of Primed sEVs for fertility preservation and the management of menopausal hormone deficiency, including early-stage ovarian insufficiency and genitourinary syndrome of menopause.
Authors
- Yu‐Tang Chin (ORCID: https://orcid.org/0000-0002-2541-3069)
- Hsien‐Chung Chiu (ORCID: https://orcid.org/0000-0001-5272-1609)
- Hui-Rong Cheng
- Chuang-Yen Huang (ORCID: https://orcid.org/0000-0003-1870-3196)
- Jiong Jiong Guo (ORCID: https://orcid.org/0000-0002-3751-5791)
- Ya‐Yu Hsieh
- Ju-Sheng Shieh
- Yu‐Hsuan Chen (ORCID: https://orcid.org/0000-0003-2270-6955)
- Fung-Wei Chang (ORCID: https://orcid.org/0000-0002-5646-4889)
- H.-L. Hsu
Institutions
- National Taiwan University (TW)
- National Penghu University of Science and Technology (TW)
- Soochow University (CN)
- Taipei City Hospital (TW)
- First Affiliated Hospital of Soochow University (CN)
- National Defense Medical Center (TW)
- National Taipei University (TW)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2025-09-01
- DOI
- https://doi.org/10.2147/ijn.s533393
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00