Exploring potential target drugs for vision-threatening diabetic retinopathy using the human plasma proteome: a Mendelian randomisation study
Our investigation elucidated the causal connections between plasma proteins, risk factors and VTDR, identified MMP8 protein as a potential drug target and highlighted seven candidate drugs. These results provide a translational framework for developing novel therapies for VTDR.
Authors
- Zijing Du (ORCID: https://orcid.org/0000-0002-8676-8293)
- Xiayin Zhang (ORCID: https://orcid.org/0000-0003-0250-0247)
- Yijun Hu (ORCID: https://orcid.org/0000-0002-6424-7905)
- Yanhua Liang (ORCID: https://orcid.org/0000-0002-3971-9341)
- Yaxin Wang (ORCID: https://orcid.org/0000-0002-4343-4541)
- Honghua Yu (ORCID: https://orcid.org/0009-0007-3308-4633)
- Yu Huang (ORCID: https://orcid.org/0000-0001-5355-0047)
Institutions
- Guangdong Academy of Medical Sciences (CN)
- Jiangmen Central Hospital (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- BMJ Open
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1136/bmjopen-2024-094669
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Guangdong Provincial People's Hospital
- Basic and Applied Basic Research Foundation of Guangdong Province