Repopulating Microglia Suppress Peripheral Immune Cell Infiltration to Promote Poststroke Recovery
Transient microglial depletion and repopulation via PLX5622 during the acute phase post stroke facilitate the recovery of neurological function. This immunomodulatory strategy offers a promising and clinically translationally relevant approach to enhance functional recovery following ischemic brain injury.
Authors
- Ziyang Jin
- Zhang Qia (ORCID: https://orcid.org/0009-0006-9711-7070)
- Zhe Zheng (ORCID: https://orcid.org/0000-0003-4866-9398)
- Ligen Shi (ORCID: https://orcid.org/0000-0001-7441-6074)
- Zhen Wang (ORCID: https://orcid.org/0000-0001-9289-4889)
- Jianming Zhang (ORCID: https://orcid.org/0000-0002-4278-0805)
- Jiarui Chen (ORCID: https://orcid.org/0000-0001-6978-9968)
- Jun Hu (ORCID: https://orcid.org/0009-0008-5619-7742)
- Lingxiao Lu (ORCID: https://orcid.org/0009-0007-9126-8924)
Institutions
- Westlake University (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1111/cns.70565
- Citations
- 2
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province