Differentiating clinically important interstitial lung abnormalities in lung cancer screening
We demonstrate a new reproducible classification of clinically important ILA/UILDs in LCS populations. We highlight that FVC shows limited associations with mortality in ILA/UILD subjects. Increased multiorgan comorbidity in ILA/UILD subjects highlights a need for comprehensive early multisystem evaluation.
Authors
- Mariia Yuneva (ORCID: https://orcid.org/0000-0003-3455-9374)
- Amyn Bhamani (ORCID: https://orcid.org/0000-0002-8575-6119)
- Joseph Jacob (ORCID: https://orcid.org/0000-0002-8054-2293)
- Neal Navani (ORCID: https://orcid.org/0000-0002-6412-7516)
- Allan Hackshaw (ORCID: https://orcid.org/0000-0002-5570-5070)
- Gísli Jenkins (ORCID: https://orcid.org/0000-0002-7929-2119)
- Priyam Verghese (ORCID: https://orcid.org/0000-0002-1319-3986)
- Carolyn Horst (ORCID: https://orcid.org/0000-0003-2427-6610)
- Nicola Smallcombe
- Daniel C. Alexander (ORCID: https://orcid.org/0000-0003-2439-350X)
- Ryoko Egashira (ORCID: https://orcid.org/0000-0001-7566-546X)
- Sophie Tisi
- Jennifer Dickson (ORCID: https://orcid.org/0000-0002-9333-8320)
- Monica L.L. Mullin (ORCID: https://orcid.org/0000-0002-0133-8826)
- Kylie Gyertson
- Chuen R Khaw
- Laura Farrelly (ORCID: https://orcid.org/0000-0002-0039-6709)
- Brintha Selvarajah (ORCID: https://orcid.org/0000-0001-8342-9117)
- Sam M. Janes (ORCID: https://orcid.org/0000-0002-6634-5939)
- Andrew Creamer (ORCID: https://orcid.org/0000-0002-9314-1210)
- Joanna C. Porter (ORCID: https://orcid.org/0000-0002-7307-169X)
- Rachel C. Chambers (ORCID: https://orcid.org/0000-0003-1370-9417)
- Helen Hall (ORCID: https://orcid.org/0000-0001-7305-8367)
- Arjun Nair (ORCID: https://orcid.org/0000-0001-9270-3771)
- Mehran Azimbagirad (ORCID: https://orcid.org/0000-0001-6321-7643)
- Ruth Prendecki
- Anne-Marie Hacker
- John McCabe
- Anand Devaraj
- Burcu Ozaltin (ORCID: https://orcid.org/0009-0009-2426-2607)
- Daisuke Yamuda
Institutions
- University College London Hospitals NHS Foundation Trust (GB)
- University of British Columbia (CA)
- Saga University (JP)
- Barts Health NHS Trust (GB)
- The Francis Crick Institute (GB)
- Royal London Hospital (GB)
- Cancer Research UK (GB)
- Harefield Hospital (GB)
- Centre for Inflammation Research (GB)
- University College London (GB)
- Kahramanmaraş Sütçü İmam University (TR)
- Imperial College London (GB)
Publication Details
- Journal
- BMJ Open Respiratory Research
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1136/bmjresp-2025-003298
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Roy Castle Lung Cancer Foundation
- Wellcome Trust
- Cancer Research UK
- National Institute for Health and Care Research
- University College London
- Rosetrees Trust
- University College London Hospitals NHS Foundation Trust
- UK Regenerative Medicine Platform
- Medical Research Council